Preventing the Unnecessary Losses of Alzheimer\u27s Disease

Educational Objectives 1. To state the importance of early detection and diagnosis of Alzheimer\u27s disease. 2. To describe common concerns of people in the early stages of Alzheimer\u27s disease. 3. To describe interventions to help people who have recently been diagnosed with Alzheimer\u27s disease or other dementias

The Notebook: An Accidental Alzheimer\u27s Awareness Campaign

My paper examines and critiques the portrayal of Alzheimer¹s disease in the popular film, The Notebook. Based off of a Nicholas Sparks novel, The Notebook uses Alzheimer¹s disease as a vehicle to relay a love story, but in doing so, presents a distorted picture of Alzheimer¹s disease to its audience. My paper compares the responsibilities of family caregivers of Alzheimer¹s patients in today¹s world with the unrealistic family caregiver, Noah, depicted on screen. My paper also explores and exposes inconsistencies between the attractive nursing home experience presented on screen and the less than ideal treatment patients experience in long term care facilities in America today. In addition, my paper uses several other films to examine and compare the emotional distress Alzheimer¹s disease patients and their families face when confronted with the condition: further underlining the idealized familial encounter with the disease depicted in The Notebook. My paper also examines the glamorized representation of Alzheimer¹s disease symptoms in the film. The misrepresentation and glamorization of Alzheimer¹s disease in The Notebook elicit serious implications in today¹s society. My paper describes how Alzheimer¹s awareness groups and other organizations utilize The Notebook as an educational tool to raise awareness for the condition, despite its imperfections. For better or worse, in today¹s society, people absorb a myriad of information from film and pop culture, leaving filmmakers with the difficult task of balancing entertainment and medicine in their films. Ultimately, my paper highlights this imbalance in The Notebook and describes its resulting accidental Alzheimer¹s awareness campaign

Amanda Hazy Wins Outstanding Thesis Award for Spring 2015

Amanda Hazy wins the Outstanding Thesis Award for Spring 2015 for her thesis, “Gene Expression and Alzheimer\u27s Disease: Evaluation of Gene Expression Patterns in Brain and Blood for an Alzheimer\u27s Disease Mouse Model.

Psychosis in Azheimer\u27s Disease

Much of the basic science literature on Alzheimer\u27s Disease (AD) reflects ongoing research into pathophysiology and neuropathology. Yet, despite reports of the association between psychotic symptoms and Alzheimer\u27s disease, relatively little is known about why such symptoms develop in certain patients and not in others. Neuroimaging and genetic studies may provide greater understanding of this association and allow clinicians and researchers to prevent, predict and treat the onset of psychotic symptoms in the future. This paper will review the current literature on the topic of psychosis in Alzheimer\u27s disease and focus on current recommendations for interventions by clinicians and caregivers

The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer\u27s disease

Introduction: This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer\u27s disease (AD): (1) the Alzheimer\u27s Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer\u27s Disease Cooperative Study–Activities of Daily Living Inventory; (3) the Neuropsychiatry Inventory; and (4) the Dependence Scale. Methods: A conceptual model depicting patient experience of mild AD was developed via literature review; concepts were compared with the items of the four measures. Relevance of the concepts included in the four measures was evaluated by patients with mild AD in a survey and follow-up interviews. Results: The four measures assessed few of the symptoms/impacts of mild AD identified within the literature. Measured items addressing emotional impacts were deemed most relevant by participants but were included in the measures only superficially. Discussion: The four assessment measures do not appear to capture the concepts most relevant to/important to patients with mild/mild-moderate AD. © 2018 The Author

Dissociation of Alzheimer's morphological pathology from cognitive impairment

We observed the Alzheimer's morphological pathology, amyloid production induces Alzheimer's cognitive impairment, was dissociated from the cognitive impairment. The earlier Alzheimer's pathological changes can be induced in normal C57BL mice, by B6 deficient feeding 4 months with no amyloid, and this cognitive and memory impairments were completely inhibited by anti-homocysteic acid antibody. According to Koch's postulate, if a pathogen of Alzheimer's disease is administrated to the normal animal, we would observe the Alzheimer's cognitive impairment in the normal animal. We actually have observed this cognitive impairment in normal C57BL male mice with no amyloid. From our observations, it is suggested the dissociation of Alzheimer's morphological pathology may be possible from the cognitive impairment

Therapeutic applications of computer models of brain activity for Alzheimer disease.

THERAPEUTIC IMPLICATIONS OF COMPUTER MODELS OF BRAIN ACTIVITY FOR ALZHEIMER DISEASE

Ciproxifan, an H~3~ Receptor Antagonist, Improves Learning and Memory in the APP Mouse Model of Alzheimer's Disease

Mice that express the mutant form of the human amyloid precursor gene associated with early-onset familial Alzheimer's disease demonstrate memory deficits and amyloid plaques. We show here that ciproxifan, a prototypical antagonist of H~3~-type histamine receptors, alleviates two types of learning and memory impairments in such mice. These data support the idea that modulation of H~3~ receptors represents a viable therapeutic strategy in the treatment of Alzheimer's disease